Laboratory for the Study of Biochemistry and Molecular Biology
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.:
Name of the institution of higher learning:
National Research Tomsk State University
Fields of scientific research:
To establish a laboratory capable of becoming a large international center of competence in biochemistry and molecular biology of copper homeostasis conducting research of membrane proteins participating in copper homeostasis using the nano-disks technology.
Project progress to date:
The laboratory specializes in identifying new functions of genes with a special focus on genes involved in the transport of metal ions through bacterial membranes. Using the nano-disks* technology, the project staff will investigate the functions of other proteins ensuring resistance to heavy metals, such as gene regulators and chaperons. Purified ionic pumps can be included in nano-disks in vitro thereby enabling to research their function. The technique will be primarily developed for expression, purification and investigation of new proteins in nano-disks, particularly, transmembrane ionic pumps.
Full Name: Solioz Marc
Link to the scientist's profile
Academic degree and title:
Doctor of Biochemistry and Microbiology, Professor
Head of the Laboratory for the Study of Biochemistry and Molecular Biology (Tomsk State University, Russia)
Professor at the Department of Physiology of Plants and Biotechnologies of the Tomsk State University Institute of Biology (Russia)
Director of "SOLIOZ SCIENTIFIC" (Berne, Switzerland)
Field of scientific interests:
Biochemistry and molecular biology of copper homeostasis in prokaryotes.
The leading scientist is a global copper expert. Over the past 20 years, he has participated in all aspects of coper biology research, such as toxicology, molecular homeostasis mechanisms, antibacterial effects of coper, human health conditions associated with copper, and the discovery of copper biomarkers. The leading scientist and his research team described the first coper pump – an enzyme that transports copper through biological membranes. This subsequently led to the discovery of the molecular causes of the Menkes and Wilson diseases in humans.