Laboratory for Perspective Study of Millimetre and Terahertz Radiation (LPSMTR)
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.:
Name of the institution of higher learning:
Novosibirsk National Research State University
Fields of scientific research:
To create an advanced world-class scientific research laboratory to investigate mitochondrial dysfunctions and mitochondrial membrane permeability mechanisms, as well as to develop new medical technologies and precise-effect pharmaceuticals for treatment of socially meaningful health conditions based on the outcomes of fundamental scientific research.
Project implementation outputs:
The project has helped establish the Laboratory for the Study of Pharmacological Regulation of Cellular Resistance that employs leading scientists and promising young researchers and graduate students. The average age of the project staff is 34 years, and the share of young employees is 66%.
The laboratory works not only to generate and apply fundamental knowledge when developing new precise-effect pharmaceuticals for treatment of various health conditions, but to also train highly skilled young researchers and prepare them for careers in biomedicine and biopharmacology. The project staff have been implementing a series of research activities designed to identify the role of phosphorylation of pore-forming proteins, as well as that of active forms of oxygen in regulation of permeability of mitochondrial membranes. The scientists continue to investigate the role of ATP-dependent potassium channel in mitochondria in regulating resistance of heart cells. The results of this research will be used to identify molecular targets for high-precision regulation of cellular resistance by using low-molecular inhibitors/modulators to enhance heart and liver cells' resistance to stress. The scientists are trying to understand the mechanism of resistance of tumour cells in multicellular structures. This research is being conducted using standard tumour cell lines, as well as original human leucosis cells (extracted from patients). Once identified, the mechanisms accounting for resistance of tumour cells will be subsequently used to develop new highly effective anti-tumour medications or new methods of therapy for oncological conditions.
Full Name: Manfred Kaspar Andreas Thumm
Link to the scientist's profile
Academic degree and title:
PhD, Engineer, Professor
Director of the Institute for Pulsed Power and Microwave Technology, Karlsruhe Institute of Technology (Germany)
Field of scientific interests:
Physics and technology of powerful impulse systems and generation of powerful microwave radiation.
Honorary doctor of the St. Petersburg State Technical University.
K. J. Button Medal from the London Institute of Physics (2000).
Award for an outstanding contribution to the development of vacuum electronics at the International Vacuum Electronics Conference (2008).
Award from the International Institute of Electrical and Electronics Engineers and Nuclear and Plasma Sciences Society (2010).
Award for innovations in plasma physics from the European Physics Society (2010).
Heinrich Hertz Award (2012).