Laboratory for the Study of Pharmacological Regulation of Cellular Resistance
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Link to the official website - missing
Grant Agreement No.:
Name of the institution of higher learning:
Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences
Fields of scientific research:
To create an advanced world-class scientific research laboratory to investigate mitochondrial dysfunctions and mitochondrial membrane permeability mechanisms, as well as to develop new medical technologies and precise-effect pharmaceuticals for treatment of socially meaningful health conditions based on the outcomes of fundamental scientific research.
Project implementation outputs:
The project has helped establish the Laboratory for the Study of Pharmacological Regulation of Cellular Resistance that employs leading scientists and promising young researchers and graduate students. The average age of the project staff is 34 years, and the share of young employees is 66%.
The laboratory works not only to generate and apply fundamental knowledge when developing new precise-effect pharmaceuticals for treatment of various health conditions, but to also train highly skilled young researchers and prepare them for careers in biomedicine and biopharmacology. The project staff have been implementing a series of research activities designed to identify the role of phosphorylation of pore-forming proteins, as well as that of active forms of oxygen in regulation of permeability of mitochondrial membranes. The scientists continue to investigate the role of ATP-dependent potassium channel in mitochondria in regulating resistance of heart cells. The results of this research will be used to identify molecular targets for high-precision regulation of cellular resistance by using low-molecular inhibitors/modulators to enhance heart and liver cells' resistance to stress. The scientists are trying to understand the mechanism of resistance of tumour cells in multicellular structures. This research is being conducted using standard tumour cell lines, as well as original human leucosis cells (extracted from patients). Once identified, the mechanisms accounting for resistance of tumour cells will be subsequently used to develop new highly effective anti-tumour medications or new methods of therapy for oncological conditions.
Full Name: Lemasters John Jay
Link to the scientist's profile
Academic degree and title:
PhD, MD, Professor
Director, Center for Cell Death, Injury and Regeneration, Medical University of South Carolina (USA),
Honorary Professor, Head of the Department Center for Advanced Cell Technology at pharmaceutical company GLAXOSMITHKLINE: UNITED STATES (North Carolina, USA)
Field of scientific interests:
Research in the field of mitochondrial pathophysiology, the role of mitochondrial dysfunction in the development and progression of various socially meaningful health conditions.
Research in the field of permeability mechanisms of external mitochondrial membranes, reorganizations of mitochondria, and how these processes are related to death of mitochondria and/or cells.
Methods of enhancing resistance of heart cells in the conditions of ischemia-reperfusion, as well as liver cells to various toxins. At present, this is one of the most promising research field in global biomedicine.
The leading scientist proposed and developed the concept of mitophagy as a mitochondria elimination mechanism that can become activated inside cells in certain pathological conditions.
He made a substantial contribution to the investigation of the role of potential-dependent anion channel (VDAC) of the external membrane of mitochondria. The channel's permeability plays an important role, particularly, in initiation of apoptosis. He performed an important investigation of the Warburg effect (the effect of low cellular oxygen content) and stability of mitochondria in maligned (cancerous) cells).
GlaxoSmithKline (UK), one of the world's largest pharmaceutical companies, has repeated appointed Lemasters as professor emeritus and a departmental head at the Center for Advanced Cellular Technologies.
Wolfson Research Merit Award from the London Royal Society for outstanding achievements in researching Lieb-Thirring inequalities (2007).