Laboratory of Expression Systems and Modification of Plant Genomes
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Link to the official website - no link
Grant Agreement No.:
Name of the institution of higher learning:
M.M. Shemyakin and Yu.A. Ovchinnikov INSTITUTE OF BIOORGANIC CHEMISTRY of the Russian Academy of Sciences
Fields of scientific research:
Leading scientist's full name: Weinstein, Alexander Mikhailovich
Academic degree and title:
Professor, head of laboratory
Field of scientific interests:
• Genetic/metabolomic/proteomic approaches to identification of new genes (regulatory and biosynthesis genes).
• Metabolic engineering of plants, cell and yeast cultures.
• Site-specific modification of genomes and genetic engineering of plants.
• Development of a potential anti-malaria drug, artemisin, within transgenic plants.
The primary scientific achievements include the following:
1. Development of the "MemoGene" technology used to engineer commercially viable agricultural crops. "MemoGene" (implemented by Danziger Innovations Ltd.) is a viral-vectors-based and tissue-culture-independent technology that makes it possible to forego traditional genetic engineering when modifying the genome of any plant.
2. Development of a genetically modified Gypsophila with red blossoms (implemented by "Dan").
3. Development of a yeast expression platform (patented) for efficient production of various metabolites in yeast, such as plant flavonoids, aromatic substances and artemisin – the precursor of anti-malaria drugs.
4. Development of a system of production of artemisin, an anti-malaria agent, in plants. The development of an experimental platform (patented) has opened up new opportunities for commercial fabrication of pharmaceuticals in plant systems.
A. Weinstein has won numerous scientific awards and prizes, occupied various managerial positions, been a member of the governing bodies of international societies and associations, and a member of the editorial boards of referenced peer-review scientific journals. During the period of 2008-2012, A. Weinstein published 18 articles in highly ranking international journals, four monographs and chapters in monographs, and acquired seven international patents.