Laboratory of Molecular Pharmacology
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.: 11.G34.31.0069
Name of the institution of higher learning:
Federal state budget educational institution of higher professional learning "St. Petersburg State Technological Institute (technical university)"
Fields of scientific research:
To research the mechanisms responsible for regulating stability of the р73 tumor suppressor using minor inhibitors of Е3-specific ITCH ubiquitin-ligase.
Key project objectives:
1. To research the impact produced by ITCH ubiquitin-ligase specific for р73 upon stability of the latter.
2. To put together a new, more specific library of molecular ITCH inhibitors.
3. To test the tumor suppressive functions of chemotherapy combined with ITCH inhibition.
4. To test ITCH inhibitors on account of their suitability for treatment of neurodegenerative conditions and inflammatory processes.
Anticipated scientific outcomes:
1. The project will help obtain a new sample of synthesized library of leads based on Е3-specific ITCH ubiquitin-ligase.
2. The project will help obtain a new sample of Е3-specific ITCH ubiquitin-ligase molecules.
3. The project will help design a new approach to studying regulation of neuron growth and control over inflammations based on participation of the E3 inhibitor of ITCH ligase.
Leading scientist's full name: Gennaro Melino
Academic degrees and titles:
M.D., Ph.D., Professor
- Department of Medicine, University of Rome Tor Vergata, Rome, Italy - Director, professor of the Department of molecular biology;
- Medical Research Board, toxicology section, Leister, Great Britain – Program leader.
Areas of scientific interest:
- Feltrinelli Prize 2009, awarded by the President of Italy,
- Antonini Award 2010, awarded by the Biochemical Society of Italy,
- Chief Editor of the "Differentiation of cell death" (Nature Publishing Group, London; impact factor: 8,192),
- Chief Editor of the "Cell death and illnesses" (Nature Publishing Group, London).