Attraction of the leading scientists to Russian institutions of higher learning, research organizations of the governmental academies of sciences, and governmental research centers of the Russian Federation

Magnetic Resonance Application Laboratory (MRAL)

About the laboratry

This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning (Resolution of the RF Government No.220 of April 9, 2010).

Link to the official website

Grant Agreement No.: 11.G34.31.0045

Name of the institution of higher learning:
Federal state budget educational institution of higher professional learning "Novosibirsk National Research State University"

Fields of scientific research:
Magnetic resonance in chemistry, biology, and medicine

Project goal:
To develop advanced methodological instruments required to analyze biologically active molecules.

Key project objectives:
1. To research the structural parameters and reactivity of short-lived radicals in biological molecules and systems;
2. To research the mechanism of chemical and enzymatic DNA repair;
3. To advance the spin hyperpolarization methodology in chemistry, biology, and medicine to enhance the NMR sensitivity;
4. To design new MRT in situ and in vivo techniques;
5. To conduct proteomic research of the eye-lens crystallines to obtain new information about cataract development;
6. To research conjugate RNA with riboflavin and NADH co-factors to understand the role of RNA in the development of life on Earth;
7. To advance high-resolution abrupt-diversion NMR techniques required to conduct new NMR experiments in relaxometry and hyperpolarization.

Anticipated scientific outcomes:
The combination of NMR biomolecule spectroscopy and spin chemistry (hyperpolarization) methods described in literature for the first time will lead to qualitative breakthroughs in chemistry, biology, and medicine.

Leading scientist

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Leading scientist's full name: Robert Captain

Link to the scientist's profile

Academic degrees and titles:
PhD, professor

Job title:
Utrecht University, honorary professor, Scientific Research Director of the Bijvoet Center for Biomolecular Research

Areas of scientific interest:
Magnetic resonance in chemistry, biology, and medicine

Scientific recognition:
1971 Golden Medal of the Royal Dutch Chemical Society
1971 Jean Servais Slas Medal (Société Chimique de Belgique)
1985 Professor A. F. Holleman award of the Royal Dutch Academy of Arts and Sciences
1989 Member of the Royal Dutch Academy of Arts and Sciences
1991 Member of the European Molecular Biology Organization
1997 Honorary member National Magnetic Resonance Society of India
2006 Royal decoration: Knight of the Order of the Dutch Lion
2006 Bijvoet Medal of Utrecht University
2008 Fellow of the International Society of Magnetic Resonance (ISMAR)
1994–2004 Member and Chairman of the Council of the International Conference on Magnetic Resonance in Biological Systems (ICMRBS)
1995–2000 Member of the Scientific Advisory Board of the EMBL, Heidelberg
1996–2002 Member of the Scientific Advisory Board of the Institute of Molecular Biotechnology (IMB), Jena
1996 Member of the Scientific Board of the École Normale Supérieure, Paris (Chemistry Department)
1997–2005 Member Council of the International Society of Magnetic Resonance (ISMAR)
1998–2009 Member of the Advisory Board of the Protein Databank (PDB)
1998–2000 Member of the Scientific Advisory Board of EMBL, Heidelberg
2000–2002 Member of the Council of EMBC/ EMBL
2000–2006 Research Director Bijvoet Center for Biomolecular Research
2002–2008 Secretary General of the Royal Dutch Academy of Arts and Sciences (KNAW)
2002–2009 Member of the Advisory Committee of the Macromolecular Structure Database, EBI, Hinxton, UK
2005 Member of the Scientific Advisory Board of the Centre for Integrated Structural Biology, Grenoble
2008 Member of the international Scientific Advisory Board of the National Institute of Chemical Physics and Biophysics (NICPB) in Tallinn, Estonia;
Member of the editorial boards of eight scientific peer review journals (e.g. "Structure", "Current Opinion in Structural Biology", "Protein and Peptide Letters" etc.).

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