Laboratory of Nano-Construction of Membrane Protein Complexes for Control over Cell Physiology
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning, research institutions of the governmental academies of sciences and governmental research centers of the Russian Federation (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.: 11.G34.31.0015
Host institution of higher learning:
State educational institution of higher professional education "Moscow Institute of Physics and Technology" (state university)
Leading scientist's full name:
Agladze, Konstantin Igorevich
Scientific research area:
To research heart tissue engineering problems.
Key project objectives:
1. To engineer heart tissue patches suitable for implantation to replace damaged heart sections;
2. To research pathological processes leading to dangerous arrhythmias, such as "re-entry" that causes disorganization of the heart muscle and undermines its ability to maintain circulation of blood;
3. To engineer an implantable patch that is fully immunologically compatible with the donor-recipient's organism.
Anticipated project outputs:
1. The project will help design substances that will make it possible to exercise photo-control over heart tissue by switching the substance from a biologically inactive form to a biologically active form and vice versa by exposing it to light waves of different lengths;
2. The project will help engineer heart tissue from pluripotent cells.
Leading scientist's full name: Agladze, Konstantin Igorevich
Academic degree and title:
Candidate of physical and mathematical sciences, professor
Head of a research laboratory at the University of Kyoto (Japan)
Field of scientific interests:
2. Self-organization processes
3. Nonlinear dynamics
Key scientific achievements:
The leading scientist's scientific works primarily have to do with the physics of excitable environments, theoretical and experimental substantiation of low-voltage defibrillation, as well as heart tissue engineering. He was one of the first scientists to use the Belousov-Zhabotinsky reaction in the capacity of a "chemical computer". He demonstrated, in particular, that wave environment could be used to process images and solve optimization problems.
Grant recipient under the following projects:
- Development of image processing systems using the Belousov-Zhabotinsky reaction, funded by the Japan Society for the Promotion of Science (1993);
- Computer-assisted prediction of chemical environments, funded by the Ministry of education of Japan (1994-1995);
- Research of chemical diodes, funded by the Japan Information and Technology Agency (1995);
- Development of computer-controlled radio-frequency catheter ablation, funded by the Italian A. Volt Foundation (1997-1998);
- Origination of excitations and their distribution at the boundary between excited environments, funded by the Russian Foundation for Fundamental Research (1998-2000);
- Testing of a computer-controlled catheter during heart surgery performed on animals, funded by NATO (1999);
- Research of formation of biofilms and dispersion mechanisms, funded by the US National Institute of Health Care (2003-2005);
- Mechanism of formation of spiral waves under the impact of the distortion effect in "cardiomyocyte" tissue cultures, funded by the Japan Society for the Promotion of Science (2009-2013).