Chemical Design of Bio-Nanomaterials for Medical Applications
This laboratory was established as part of a scientific research project supported with a monetary grant awarded by the Government of the Russian Federation under a grant competition designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning, research institutions of the governmental academies of sciences and governmental research centers of the Russian Federation (Resolution of the RF Government No.220 of April 9, 2010).
Grant Agreement No.: 11.G34.31.0004
Host institution of higher learning:
State educational institution of higher professional education "Moscow State University named after M. V. Lomonosov"
Scientific research area:
To chemically develop new bio-nanomaterials for medical applications.
Key project objectives:
1. To develop and characterize antioxidant nanozymes – complexes and conjugates of antioxidant enzymes and block ionomeres as neuroprotective and anti-inflammatory agents;
2. To develop and characterize bacteriolytic nanozymes – potential antibacterial agents;
3. To develop nanozymes with inbuilt magnetic nanoparticles for theranostics (combination of diagnostics and therapy);
4. To develop hydrolytic nanozymes capable of utilizing organophosphates and pesticides.
Anticipated project outputs:
The "NanoZYME" technology developed by the leading scientist (enzymes encapsulated in nanosized polymer shells) will make it possible to develop medications that can be used to treat a wide scope of human health conditions, including stroke, Alzheimer's disease, Parkinson's disease, vascular dementia, hypertension combined with congestive heart failure, etc. The project will help create new nanozymes based on antioxidant enzymes, particularly, the Russian drug superoxide dismutase, to treat eye disorders, spine injuries, and other health conditions. The project scientists plan to develop new classes of nanozymes that will offer a fundamentally new approach to antibacterial therapy that will be free of antibiotic resistance.
The project scientists are working to develop hydrolytic nanozymes to treat and prevent poisoning by organophosphate compounds, including conditions associated with delayed neurotoxicity.
The project team plans to develop fundamentally new nanoparticles capable of penetrating the nidus in human body. They can be remotely activated by external magnetic fields to provide non-invasive treatment (preserving the integrity of skin surfaces). Doctors will be able to inject such magnetically controlled nanoparticles into the patient's body, wait until they take their designated positions in the nidus (in some cases they will be able to monitor their positions using remote visualization methods, such as magnetic-resonance spectroscopy), and then "turn them on" by using an external trigger.
Leading scientist's full name: Kabanov, Alexander Viktorovich
Academic degree and title:
Doctor of chemical sciences, professor
Professor, Director of the Center for Medication Delivery and Nanomedicine at the University of Nebraska Medical Center in Park Davis (USA); head of the "Chemical Design of Bio-Nanomaterials" laboratory at the Moscow State University.
Field of scientific interests:
1. Polymer nanosystems capable of delivering biologically active compounds.
- Lenin Komsomol Prize winner, 1988;
- University of Nebraska Prize for outstanding scientific and creative achievements, 2007;
- University of Nebraska Medical Center Prize winner, 2009.
In July 2012, the leading scientist relocated to the University of North Carolina where he is now a professor and the Director of the Center for Nanotechnologies and Medication Delivery at the University of North Carolina Eshelman School of Pharmacy in Chapel Hill (USA) and a Co-Director of the Institute of Nanomedicine of North Carolina.
• Federal Law of the Russian Federation No.308-FZ of December 2, 2009 "On the federal budget for FY 2010 and the planned period of 2011 and 2012" (on the website of the "Rossiyskaya Gazeta").
• Federal Law of the Russian Federation No.308-FZ of December 2, 2009 "On the federal budget for FY 2010 and the planned period of 2011 and 2012" (on the website of the President of Russia, 1,423 pages).
• Resolution of the Government of the Russian Federation No.220 of April 9 "On measures designed to attract the world's leading scientists to Russian institutions of higher learning".
• List of winners of the first open grant competition of the Government of the Russian Federation designed to provide governmental support to scientific research projects implemented under the supervision of the world's leading scientists at Russian institutions of higher learning.
• Other documents related to the problem of attracting the world's leading scientists to Russian institutions of higher learning (on the website of the Ministry of education and science of the Russian Federation).