Laboratory for Non-Mendelian inheritance
Grant Agreement No.: 14.Y26.31.0024
Project name: Non-Mendelian inheritance: conserved mechanisms of parent-of-origin effects
Name of the institution of higher learning: Novosibirsk State University
Fields of scientific research: Biology
Purpose is to elucidate, in concrete molecular and cellular terms, the volutionarilyconserved molecular mechanism of parent-of-origin effects in animals.
Name: Singh Prim
Academic degree and title: PhD
Job Title: Principal Investigator, School of Natural Sciences and Psychology, Liverpool John Moores University
Field of scientific interests: Gene expression, molecular biology, epigenetics, heterochromatin
1984 - Bye-Fellowship Cambridge University
1986 - Biotechnology and Biological Sciences Research Council Research Fellow, UK Government
Scientific work of the leading scientist, his/her main scientific achievements:
Dr. Prim Singh is one of the leading researchers in the field of genetics.
1984-1985: Bye-Fellow of Magdalene College, Cambridge University, UK.
1988 - 1996: BBSRC Research Fellow, BBSRC Babraham Institute, Cambridge, UK.
1996-1999: Principal Investigator and subsequent Head of Chromatin Function Laboratory, BBSRC Babraham Institute, CAMBRIDGE, UK.
1999-2004: Principal Investigator and Head, Nuclear Reprogramming Laboratory,
BBSRC Roslin Institute, EDINBURGH, UK. .
2004-2008: Principal Investigator, Division of Tumor Biology, Research Center
Borstel, Parkallee 22, 23845-Borstel, GERMANY.
2008-2011: Principal Investigator, Division of Immuno-epigenetics, Research
Center Borstel, Parkallee 22, 23845-Borstel, GERMANY.
2011-2014: Principal Investigator, Fächereverbund Anatomie, Institut für Zell und
Neurobiologie, Charite-Universitätsmedizin,10117 Berlin, GERMANY.
2014-present: Principal Investigator, Natural Sciences
Newman, Andrew, Bessa, Paraskevi, Tarabykin, Victor and Singh, Prim, B. Activity-DEPendent Transposition 2017 Embo Reports
Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez-Nieto, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P. Brown, Anna Marazuela-Duque, Prim B. Singh, Lourdes Serrano and Alejandro Vaquero An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions 2017 Epigenetics
Anna Mattout, Yair Aaronson, Sailaja BS, Edupuganti V Raghu Ram, Arigela Harikumar , Jan-Philipp Mallm, Kae Hwan Sim, Emmanuelle Supper, Prim B. Singh, Sze Siu Kwan,
Karsten Rippe and Eran Meshorer Heterochromatin Protein 1 beta (HP1 beta) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells 2015 Genome Biology
Maria Manukyan and Prim B. Singh Epigenome rejuvenation: HP1 beta mobility as a measure of pluripotent and senescent chromatin ground states 2014 Scientific Reports
Irina A. Maksakova, Preeti Goyal, Peter J. Thompson, Steven Jones, Prim B. Singh, Mohammad M. Karimi and Matthew C. Lorincz. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells 2013 Epigenetics & Chromatin