Protein synthesis laboratory
Grant Agreement No.: 14.W03.31.0012
Project name: Protein synthesis in aging and lifespan control
Name of the institution of higher learning: Lomonosov Moscow State University
Fields of scientific research: Biology
1: Systems level analysis of protein synthesis in live animals.
• Utilize novel applications of ribosome profiling to characterize protein synthesis in various organs of mice;
• Identify alternative start codons and define protein isoforms in these organs; and
• Apply these approaches to naked mole rats, which are mouse-sized rodents that live 10 times longer than mice.
2: Determine rates and features of protein synthesis in various organs in a species-, organ-, protein-, and diet-specific manner.
• Determine rates of protein synthesis at the level of organs and individual proteins in mice and naked
• Characterize regulation of protein synthesis by age and calorie restriction, as well as their influence on
footprint length, ribosome density, metagene properties, ribosomal pauses, and different protein
• Characterize parallel regulation of protein expression at the level of transcript abundance and protein
synthesis in the organs of mammals.
Gladyshev Vadim Nikolaevich
Date of Birth: 03.01.1966
Academic degree and title: Professor
Job Title: Brigham and Women's Hospital and Harvard Medical School
Field of scientific interests: Biology of longevity; ribosome profiling; redox biology; selenoproteins
Since 2009 - Professor of Medicine, Harvard Medical School (USA)
Since 2009 - Director of Center for Redox Medicine (Brigham & Women’s Hospital, USA)
Since 2009 - Associate Member of Broad Institute of Harvard and MIT, USA
Since 2009 - Full Member of Dana-Farber/Harvard Cancer Center, USA
Since 2009 - Senior Geneticist, Department of Medicine, Brigham & Women’s Hospital,USA