Attraction of the leading scientists to Russian institutions of higher learning, research organizations of the governmental academies of sciences, and governmental research centers of the Russian Federation

Protein synthesis laboratory

About Laboratory

Grant Agreement No.: 14.W03.31.0012

Project name: Protein synthesis in aging and lifespan control

Name of the institution of higher learning: Lomonosov Moscow State University

Fields of scientific research: Biology

1: Systems level analysis of protein synthesis in live animals.

We will:

• Utilize novel applications of ribosome profiling to characterize protein synthesis in various organs of mice;

• Identify alternative start codons and define protein isoforms in these organs; and

• Apply these approaches to naked mole rats, which are mouse-sized rodents that live 10 times longer than mice.

2: Determine rates and features of protein synthesis in various organs in a species-, organ-, protein-, and diet-specific manner.

We will:

• Determine rates of protein synthesis at the level of organs and individual proteins in mice and naked

mole rats;

• Characterize regulation of protein synthesis by age and calorie restriction, as well as their influence on

footprint length, ribosome density, metagene properties, ribosomal pauses, and different protein

isoforms; and

• Characterize parallel regulation of protein expression at the level of transcript abundance and protein

synthesis in the organs of mammals.

Leading scientist


Gladyshev Vadim Nikolaevich


Date of Birth: 03.01.1966

Citzenship: Russia

Academic degree and title: Professor

Job Title: Brigham and Women's Hospital and Harvard Medical School

Field of scientific interests:  Biology of longevity; ribosome profiling; redox biology; selenoproteins

Academic recognition:

Since 2009 - Professor of Medicine, Harvard Medical School (USA)

Since 2009 - Director of Center for Redox Medicine (Brigham & Women’s Hospital, USA)

Since 2009 - Associate Member of Broad Institute of Harvard and MIT, USA

Since 2009 - Full Member of Dana-Farber/Harvard Cancer Center, USA

Since 2009 - Senior Geneticist, Department of Medicine, Brigham & Women’s Hospital,USA

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